C4d staining in allograft biopsies
نویسندگان
چکیده
منابع مشابه
C4d staining of renal allograft biopsies: a comparative analysis of different staining techniques.
BACKGROUND Detection of C4d along peritubular capillaries (PTC) in renal allograft biopsies is an independent prognostic marker of poor long-term graft survival. It is typically associated with circulating donor-specific antibodies. Since only little information is available on the best technique to stain C4d, we compared the two methods most often used for detecting C4d in renal allograft spec...
متن کاملC4d staining in renal allograft biopsies with early acute rejection and subsequent clinical outcome.
BACKGROUND AND OBJECTIVES Diffuse C4d staining in peritubular capillaries (PTCs) during an acute rejection episode (ARE) is the footprint of antibody-mediated rejection. In current clinical practice, diffuse C4d+ staining during acute rejection is regarded as an inferior prognostic sign. This case-control study investigated the prognostic role of mere C4d staining for graft outcome during an AR...
متن کاملComparison of C4d immunostaining methods in renal allograft biopsies.
Immunostaining of renal allograft biopsies for C4d deposition has become an important diagnostic tool in the recognition of humoral-mediated graft rejection. The majority of studies have been performed on frozen tissue sections with one of several commercially available antibody reagents. However, only a single small series that compared reagents or methods, including staining of formalin-fixed...
متن کامل4d Staining of Pulmonary Allograft Biopsies: An mmunoperoxidase Study
ackground: The role of antibody-mediated/humoral rejection in lung allografts is not fully elucidated. In other organ systems, deposition of a specific complement product, C4d, is a sensitive and specific marker for humoral rejection. C4d can be evaluated in tissue biopsies by immunofluorescence or light microscopic immunohistochemical staining techniques. Using immunohistochemical staining tec...
متن کاملCapillary Deposition of Complement C4d and C3d in Chinese Renal Allograft Biopsies
BACKGROUND C3d is a product of both the classic and the alternative complement cascades; however, few studies have addressed the role of C3d in renal biopsies and its relationship with long-term graft survival rate is not very clear. METHODS 94 patients with biopsy-proven acute rejection episodes were included in the study. We investigated the associations between histological findings, clini...
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ژورنال
عنوان ژورنال: Indian Journal of Nephrology
سال: 2012
ISSN: 0971-4065
DOI: 10.4103/0971-4065.97155